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Congratulations! The research article on CNS drug delivery by postdoctoral researcher Xize Gao et al. has been published in Cell.
Gaoet al. hijacked calvarial immune cells using drug-loaded nanoparticles and leveraged their intrinsic migratory capacity through skull-meningeal microchannels to bypass the blood-brain barrier for targeted CNS drug delivery. In ischemic stroke mouse models, this delivery strategy has demonstrated promising therapeutic efficacy compared to conventional approaches, Read more.
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Congratulations! Ph.D. students Ziheng Tang, Chengqian Cui et al. pulished an article about MoS2/PbS phototransistors in Advanced Science.
Tang et al. investigate the band structure of vertical and lateral MoS2/PbS heterojunctions via ab initio calculations and find that lateral heterojunctions in heterostructures dominate the bandgap tunability via tuning of the Type-II band alignment. To achieve wafer-scale uniformity, we investigated how plasma treatment modulates the thin-film surface energy, and the results substantially improved fabrication scaling of MoS2/PbS heterojunctions from traditional micro-scale level to an incredible 4-inch wafer-scale with near-ideal yields (97%) and enabled bandgap tunability (from 1.24 to 0.61 eV), Read more.
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Congratulations! The research article on piezoelectric nanotransducers for wireless neurostimulation by Ph.D. students Chengqian Cui & postdoctoral researcher Xize Gao et al. has been accepted by ACS nano.
Cui et al. proposed an aggregation-enhanced piezoelectric nanotransducer for wireless neurostimulation under low-intensity focused ultrasound. This design enables efficient ultrasound-driven activation of voltage-gated ion channels in vitro and selective modulation of spatially distinct cortical regions in rats, as confirmed by robust ECoG and EMG responses, neuronal activation, and favorable biocompatibility. Further details will be presented in upcoming articles scheduled for official release, Read more.
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Liu et al. present a miniaturized wireless brain-machine interface (BMI) integrated with custom-designed 120-channel μECoG arrays, engineered for monitoring brain activities in freely behaving marmosets. The BMI can capture and characterize behavior-specific neural signals, including drinking-related activation, pre-vocalization anticipatory responses, and vigilance-induced transient responses enabling advanced studies of neural mechanisms underlying natural primate behaviors.
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Recently, the 4th IEEE International Conference on Micro/Nano Sensors for AI, Healthcare, and Robotics (IEEE-NSENS 2025) was held in Kuala Lumpur, Malaysia. Prof. MingJun Zhang gave the plenary talk named as “Embodied Intelligence Brain-machine Interface“. PhD students Chengqian Cui, Xize Gao, and Nianzhen Du delivered oral presentations. Among them, the paper co-authored by Cui Chengqian and Gao Xize was awarded the conference’s sole Best Conference Paper Award.
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Sheng et al present a modular multimodal brain-machine interface (BMI) device capable of adapting different configurations, modalities, and capabilities. The modular device can be configured to support neurorecording, neurostimulation, and drug delivery, and its unified interfaces facilitates plug-andplay usage. The applicability of the BMI was demonstrated across four scenarios, including closed-loop seizure modulation in free-moving rats, cortical and depth recording in swine, alpha wave detection in humans, and directional neurostimulation in vitro.
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Ph. D. student Xize Gao Enter the Student Paper Competition Finalist at the IEEE EMBC 2024 Conference.
The 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, was held in Orlando, Florida, USA, July 15-19, 2024. As social determinants of health take on an ever-important role, the conference theme, “Technology and its promise for equity and access for well-health,” addresses the great potential impacts that engineers can provide to the whole of society. Prof. Zhang and Xize Gao attended this meeting with a conference paper “Hitchhiking calvaria immune cells to bypass BBB for CNS drug delivery through transcranial nanoparticle microinjection”.
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The National Natural Science Foundation of China (NSFC) reports the latest research progress of our group.
Recently, the National Natural Science Foundation of China (NSFC) reported the latest research progress of our group on its official website, “Under the National Natural Science Foundation of China (NSFC) project (Grant Nos. 62173200, 62350710211, and 62173198).
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Ph.D. students Xize Gao et.al. published an article in Science Advances.
Inspired by the expansion of the spiny dolphin, the team of Professor Mingjun Zhang from Tsinghua University School of Medicine and Associate Professor Jing Xu from the Department of Mechanics have jointly developed a painless and biodegradable drug-delivery robot that uses intestinal peristalsis to drive microneedles into the intestinal wall.